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Medchemexpress LLC BI-3231 | 2894848-07-6 | 99.8% | 380.37 | 500 MG
Supplier: Medchemexpress LLC HY148814500MG
BI-3231 is a chemical probe that functions as a potent and selective inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13). It exhibits IC50 values of 1 nM for human HSD17B13 and 13 nM for mouse HSD17B13. This compound holds potential for research into nonalcoholic steatohepatitis (NASH) and various other liver diseases. The BI-3231 probe was developed by Boehringer Ingelheim and is available for free through their open innovation portal, opnMe.com, alongside its negative control.
- Potent and selective HSD17B13 inhibitor.
- IC50 values: 1 nM (hHSD17B13) and 13 nM (mHSD17B13).
- Potential for research in nonalcoholic steatohepatitis (NASH) and liver diseases.
- High metabolic stability in liver microsomes.
- Moderate metabolic stability in hepatocytes.
- Rapidly cleared from plasma, with considerable hepatic exposure maintained over 48 hours in vivo.
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