Medchemexpress LLC BI-4020 | 2664214-60-0 | 99.3% | 10 MG

Supplier:  Medchemexpress LLC HY12955010MG

BI-4020 is a fourth-generation, orally active, and non-covalent EGFR tyrosine kinase inhibitor. It inhibits the triple mutant EGFR del19 T790M C797S variant (IC50=0.2 nM in BaF3 cell lines), the double mutant EGFR del19 T790M, and primary mutant EGFR del19 (IC50=1 nM). It also shows activity against EGFR wt (IC50=190 nM). This product demonstrates high kinome selectivity and good DMPK properties and is for research use only.

• Fourth-generation, orally active, and non-covalent EGFR tyrosine kinase inhibitor
• Inhibits triple mutant EGFR del19 T790M C797S variant (IC50=0.2 nM)
• Inhibits double mutant EGFR del19 T790M and primary mutant EGFR del19 (IC50=1 nM)
• Shows activity against EGFR wt (IC50=190 nM)
• Demonstrates high kinome selectivity and good DMPK properties
• Leads to tumor regressions in human PC-9 triple mutant NSCLC xenograft model in mice

Catalog No. 50-003-40700