Medchemexpress LLC BI-4020 | 2664214-60-0 | 99.3% | 25 MG

Supplier:  Medchemexpress LLC 25MGHY129550

BI-4020 is a fourth-generation, orally active, and non-covalent EGFR tyrosine kinase inhibitor. It inhibits the triple mutant EGFR del19 T790M C797S variant with an IC50 of 0.2 nM in BaF3 cell lines, as well as the double mutant EGFR del19 T790M and primary mutant EGFR del19 (IC50=1 nM). This inhibitor also shows activity against EGFR wt (IC50=190 nM) and exhibits high kinome selectivity and good DMPK properties. It is for research use only.

• Fourth-generation, orally active, and non-covalent EGFR tyrosine kinase inhibitor
• Inhibits triple mutant EGFR del19 T790M C797S variant with an IC50 of 0.2 nM
• Inhibits double mutant EGFR del19 T790M and primary mutant EGFR del19 with an IC50 of 1 nM
• Shows activity against EGFR wt (IC50 = 190 nM)
• Exhibits high kinome selectivity and good DMPK properties
• Intended for research use only

Catalog No. 50-003-39695