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Medchemexpress LLC BI-4020 | 2664214-60-0 | 99.3% | 542.68 | 5 MG
SDP

Catalog No. 5000364577
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BI-4020 is a fourth-generation, orally active, and non-covalent EGFR tyrosine kinase inhibitor. It exhibits high kinome selectivity and good DMPK properties, making it a promising compound for research applications.

  • Inhibits the triple mutant EGFR del19 T790M C797S variant with an IC50 of 0.2 nM.
  • Inhibits the double mutant EGFR del19 T790M and primary mutant EGFR del19 with an IC50 of 1 nM.
  • Demonstrates activity against EGFR wt with an IC50 of 190 nM.
  • Leads to tumor regressions in NSCLC xenograft models in mice.

Catalog No. 50-003-64577 Supplier Medchemexpress LLC Supplier No. 5MGHY129550
May include imposed supplier surcharges.
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BI-4020 is a fourth-generation, orally active, and non-covalent EGFR tyrosine kinase inhibitor. It exhibits high kinome selectivity and good DMPK properties, making it a promising compound for research applications.

  • Inhibits the triple mutant EGFR del19 T790M C797S variant with an IC50 of 0.2 nM.
  • Inhibits the double mutant EGFR del19 T790M and primary mutant EGFR del19 with an IC50 of 1 nM.
  • Demonstrates activity against EGFR wt with an IC50 of 190 nM.
  • Leads to tumor regressions in NSCLC xenograft models in mice.

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