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Medchemexpress LLC BI-4142 | 2682003-36-5 | 96.5% | 521.57 | 25 MG
Supplier: Medchemexpress LLC 25MGHY150024
BI-4142 is a potent, highly selective, and orally active HER2 inhibitor with an IC50 of 5 nM. It demonstrates antiproliferative activity against tumor cells and inhibits tumor growth and oncogenic signaling in animal models. The compound exhibits good permeability and no PgP-mediated efflux liability in the CaCo-2 assay.
- Potent, highly selective, and orally active HER2 inhibitor
- IC50 of 5 nM against HER2
- Inhibits tumor growth and oncogenic signaling
- Displays good permeability and no PgP-mediated efflux liability
- Inhibits HER2-dependent cell lines and downstream signaling
- Target: EGFR, JAK/STAT Signaling, Protein Tyrosine Kinase/RTK
- Soluble in DMSO at 100 mg/mL (191.73 mM)
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