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Apexbio Technology LLC BI 6015 93987-29-2 5mg
Supplier: Apexbio Technology LLC B56685
BI 6015 is a small-molecule antagonist targeting hepatocyte nuclear factor 4 alpha (HNF4 ) a nuclear receptor implicated in transcriptional regulation within liver intestinal and pancreatic -cells It is designed to inhibit HNF4 -mediated transcriptional activation thereby modulating gene expression related to glucose and lipid metabolism BI 6015 exerts its biological activity primarily through direct antagonism of HNF4 leading to reduced transcriptional activation and lowering endogenous HNF4 protein levels In cell-based studies BI 6015 demonstrates inhibition of insulin promoter activity and suppression of endogenous insulin expression in T6PNE cells as well as decreased HNF4 protein in MIN6 and HepG2 cells Based on these pharmacological properties BI 6015 holds research potential in the study of diabetes and hepatic metabolic regulation
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