Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC BI-7273 1883429-21-7 5mg
Supplier: Apexbio Technology LLC B61965
BI-7273 (CAS 1883429-21-7) is a selective small-molecule inhibitor targeting the bromodomains of BRD9 and BRD7 with reported IC50 values of 19 nM and 117 nM respectively BRD9 is a component of the SWI/SNF chromatin remodeling complex implicated in the proliferation of acute myeloid leukemia (AML) cells BI-7273 demonstrates effective disruption of BRD9 function in vitro and also engages BRD7 due to high sequence homology between their bromodomains Biochemical assays indicate negligible activity against BET family bromodomains even at high concentrations In vivo oral administration in mouse models shows dose-dependent systemic exposure BI-7273 is currently utilized as a chemical probe in preclinical studies investigating BRD9/BRD7 modulation in hematological malignancies
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?