Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC BI-749327 | 2361241-23-6 | 99.9% | 442.43 | 1 MG
Supplier: Medchemexpress LLC HY1119251MG
BI-749327 is a potent, highly selective, and orally bioavailable TRPC6 antagonist. It demonstrates significant selectivity, being 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7. In vitro, it suppresses NFAT activation and blocks signaling of prohypertrophic genes in isolated myocytes.
- Potent and selective TRPC6 antagonist
- Orally bioavailable
- Suppresses NFAT activation in HEK293T cells
- Blocks prohypertrophic gene expression in isolated myocytes
- Improves left heart function and reduces volume/mass ratio in vivo
- Reduces renal fibrosis in vivo
- Long terminal half-life in mice
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?