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Medchemexpress LLC BI-749327 | 2361241-23-6 | 99.9% | 442.43 | 100 MG
Supplier: Medchemexpress LLC HY111925100MG
BI-749327 is a potent, highly selective, and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM, and 15 nM for mouse, human, and guinea pig TRPC6, respectively. It is 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7.
- Potent, highly selective, and orally bioavailable TRPC6 antagonist.
- Suppresses NFAT activation in HEK293T cells.
- Blocks associated signaling and expression of prohypertrophic genes in isolated myocytes.
- Improves left heart function.
- Reduces renal fibrosis.
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