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Medchemexpress LLC BI-847325 | 1207293-36-4 | 98.15% | 464.56 | 50 MG
Supplier: Medchemexpress LLC HY1895550MG
BI-847325 is an ATP competitive dual inhibitor of MEK and aurora kinases (AK). It inhibits the growth and survival of both treatment-naive and drug-resistant melanoma cell lines, decreasing the expression of MEK and Mcl-1 while increasing the expression of pro-apoptotic protein Bim. This compound is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- ATP competitive dual inhibitor of MEK and aurora kinases
- Inhibits MEK2 with an IC50 of 4 nM
- Inhibits aurora kinases with IC50 values of 15 nM for AK-C and 25 nM for AK-A
- Inhibits LCK (5 nM) and MAP3K8 (93 nM) at 1,000 nM
- Induces apoptosis in treatment-naive and drug-resistant xenografted melanoma in vivo
- Click chemistry reagent with an Alkyne group
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