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Medchemexpress LLC BI-9564 | 1883429-22-8 | MFCD09930810 | 98.7% | 353.41 | 5 MG
Supplier: Medchemexpress LLC 5MGHY100352
BI-9564 is a potent, selective, and cell-permeable BRD9/BRD7 bromodomains inhibitor.
- Potent, selective, and cell-permeable BRD9/BRD7 bromodomains inhibitor.
- IC₅₀ of 75 nM for BRD9 and 3.4 μM for BRD7.
- Kds of 14 nM for BRD9 and 239 nM for BRD7.
- Highly selective, with an IC₅₀ > 100 μM for BET family.
- Shows no activity against 324 kinases (<5 μM).
- Antiproliferative effect on human acute myeloid eosinophilic leukemia cell line EOL-1 (EC₅₀ 800 nM).
- More than 10-fold selective for BRD9 over the highly homologous bromodomain BRD7.
- Attractive ADME/PK profiles for in vivo proof-of-concept studies.
- Results in additional survival benefit in a xenograft model of human AML.
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