Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC BI-9627 (hydrochloride) | 1422252-46-7 | 98.0% | 392.80 | 1 ML
Supplier: Medchemexpress LLC HY1807110MM/1ML
BI-9627 hydrochloride is a potent and selective sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, demonstrating over 30-fold selectivity against NHE2. It has been shown to decrease autophagy in HTR-8/SVneo cells, significantly reduce the pHi of human sperm, and prolong Ca2+ recovery time in KO hiPSC-CMs. This compound exhibits low drug-drug interaction potential, excellent pharmacokinetics in rat and dog models, and potent activity in isolated heart models of ischemia-reperfusion injury.
- Potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor
- Over 30-fold selectivity against NHE2
- Decreases autophagy in HTR-8/SVneo cells
- Significantly reduces pHi of human sperm
- Prolongs Ca2+ recovery time in KO hiPSC-CMs
- Low drug-drug interaction potential
- Excellent pharmacokinetics in rat and dog models
- Potent activity in isolated heart models of ischemia-reperfusion injury
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?