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Medchemexpress LLC BI-9627 hydrochloride | 1422252-46-7 | 98.0% | 392.80 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY18071A

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BI-9627 hydrochloride is a potent and selective sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50 values of 6 nM and 31 nM. It demonstrates high selectivity over other NHE isoforms and has shown effects on autophagy, pH regulation, and Ca2+ recovery in various cell types. This compound exhibits favorable pharmacokinetic properties and cardioprotective activity. For research use only.

  • Potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor (IC50 = 6 and 31 nM).
  • High selectivity (>30-fold) against NHE2; no activity against NHE3.
  • Decreases autophagy in HTR-8/SVneo cells.
  • Reduces pHi of human sperm and partially reverses DMA effect.
  • Prolongs Ca2+ recovery time in KO hiPSC-CMs.
  • Low drug-drug interaction (DDI) potential.
  • Excellent pharmacokinetics in rat and dog.
  • Potent activity in isolated heart model of ischemia-reperfusion injury.

Catalog No. 50-003-84890


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