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Medchemexpress LLC BI-9627 hydrochloride | 1422252-46-7 | 98.0% | 392.80 | 50 MG
Supplier: Medchemexpress LLC HY18071A50MG
BI-9627 hydrochloride is a potent inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1), with IC50 values of 6 nM in intracellular pH recovery (pHi) assays and 31 nM in human platelet swelling assays. It demonstrates over 30-fold selectivity against NHE2 and shows no measurable inhibitory activity against the NHE3 isoform.
- Decreases autophagy in HTR-8/SVneo cells and reduces human sperm pHi.
- Prolongs Ca2+ recovery in hiPSC-CMs; potent in ischemia-reperfusion injury models.
- Low drug-drug interaction (DDI) potential; excellent pharmacokinetics in rat and dog.
- Off-white to light yellow solid appearance.
- Soluble in DMSO (100 mg/mL) and H2O (4.17 mg/mL).
- Solid storage at 4°C; stock solutions at -80°C (6 months) or -20°C (1 month).
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