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Medchemexpress LLC BI-9627 (hydrochloride) | 1422252-46-7 | 98.01% | 392.80 | 100 MG
Supplier: Medchemexpress LLC HY18071100MG
BI-9627 hydrochloride is a potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor with IC50 values of 6 nM in intracellular pH recovery (pHi) and 31 nM in human platelet swelling assays. It exhibits over 30-fold selectivity against NHE2 and shows no measurable inhibitory activity against the NHE3 isoform. This compound demonstrates low DDI potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury.
- Decreases autophagy in HTR-8/SVneo cells
- Significantly reduces the pHi of human sperm
- Partially reverses the effect of DMA
- Prolongs Ca2+ recovery time in KO hiPSC-CMs
- For research use only
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