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Medchemexpress LLC BI 99179 | 1291779-76-4 | 99.38% | 391.46 | 5 MG
Supplier: Medchemexpress LLC 5MGHY16100
BI 99179 is a chemical probe that acts as a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM. It is a tool compound suitable for in vivo validation of FAS as a target for lipid metabolism-related diseases and shows significant peripheral and central exposure upon oral administration in rats.
- Potent in mouse hypothalamic N-42 cells with an IC50 of 0.6 μM.
- No significant LDH release in cytotoxicity assays up to 30 μM.
- Exhibits antiproliferative efficacy in human glioma GAMG cells.
- Possesses a super pharmacokinetic profile in male Han/Wistar rats.
- For research use only.
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