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Medchemexpress LLC Bi-D1870 | 501437-28-1 | MFCD11223662 | 99.4% | 391.42 g·mol⁻¹ | C19H23F2N5O2 | 1 ML
Supplier: Medchemexpress LLC HY1051010MM 1ML
BI-D1870 is a cell-permeable, ATP-competitive inhibitor of p90 ribosomal S6 kinase (RSK) isoforms 1-4 that is used in biochemical and cell-based studies to probe RSK-dependent signaling. It preferentially targets the N-terminal kinase domain and has been reported to be brain penetrant.
- ATP-competitive inhibitor of RSK isoforms (RSK1-4)
- Potent IC50s: RSK1 31 nM; RSK2 24 nM; RSK3 18 nM; RSK4 15 nM
- Cell permeable and reported to be brain penetrant
- Acts at the N-terminal kinase domain of RSK
- Available as solid or as a 10 mM solution in DMSO (1 mL)
- Typical purity approximately 99.4%
- Suitable for biochemical and cell-based studies of RSK signaling
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