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Apexbio Technology LLC BIBR 1532 321674-73-1 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A19455.1
BIBR 1532 (CAS 321674-73-1) is a selective non-nucleosidic inhibitor of telomerase exhibiting an IC50 of approximately 93 nM It targets human telomerase reverse transcriptase (hTERT) reducing enzymatic activity and causing telomere shortening Mechanistically BIBR 1532 suppresses cancer cell proliferation and induces apoptosis by modulating c-Myc and hTERT transcription elevating pro-apoptotic signaling through p73 Bax/Bcl-2 ratio and caspase-3 activation It has demonstrated inhibitory effects on proliferation and survival in several leukemia cell lines including pre-B acute lymphoblastic leukemia and acute promyelocytic leukemia (NB4) highlighting its utility in oncology research
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