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Medchemexpress LLC Binimetinib | 606143-89-9 | C17H15BrF2N4O3 | 1 G
Supplier: Medchemexpress LLC HY152021G
Binimetinib is an oral and selective MEK1/2 inhibitor that inhibits MEK with an IC50 of 12 nM. This compound is primarily utilized in research for its role in the MAPK/ERK pathway and autophagy.
- Potent and selective MEK1/2 inhibitor with an IC50 of 12 nM.
- Targets MEK and autophagy, impacting the MAPK/ERK pathway.
- Blocks basal ERK phosphorylation in HRAS mutant cell lines.
- Demonstrates synergistic effects in combination treatments.
- Reverses resistance in RSK-expressing cells when combined with PI3K inhibition.
- Reduces disease severity and joint destruction in animal models of arthritis.
- Enhances efficacy when used in combination therapies for inflammation and tumor growth.
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