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FOCUS BIOMOLECULES Biochemical Reagents, A83-01, ALK inhibitor, CAS 909910-43-6, 98% by TLC/NMR (Conforms)
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Biochemical Reagents, A83-01, ALK inhibitor, CAS 909910-43-6, 98% by TLC/NMR (Conforms), Potent and selective ALK4, 5 and 7 inhibitor1,2. IC5045, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFbeta2. Inhibits differentiation of rat induced pluripotent stem cells and increases clonal expansion efficiency3. Together with AMI-5, A83-01 enabled Oct4-induced reprogramming of mouse embryonic fibroblasts4. Cell permeable. Active in vivo.

Catalog No. NC3802459


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