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FOCUS BIOMOLECULES Biochemical Reagents, I2, ERO1A inhibitor, CAS Unknown, 98% by TLC/NMR (Conforms)
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Catalog No. NC3797286
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Biochemical Reagents, I2, ERO1A inhibitor, CAS Unknown, 98% by TLC/NMR (Conforms), I2 is an inhibitor of the oxidoreductase ERO1A (IC50 8.1 uM), a mediator of the unfolded protein response (UPR).1 Under cancer-related hypoxia conditions, ERO1A favors the folding of the angiogenic protein VEGFA leading to cancer cell growth and spread. I2 inhibited the metabolic activity of DMA-MB-231 triple negative breast cancer cells and impaired migration and VEGF secretion. Tumors in C57/BL6Jmice showed decreased levels of VEGF and PD-L1 when treated with I2.

Catalog No. NC3797286 Supplier FOCUS BIOMOLECULES Supplier No. 104908
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Biochemical Reagents, I2, ERO1A inhibitor, CAS Unknown, 98% by TLC/NMR (Conforms), I2 is an inhibitor of the oxidoreductase ERO1A (IC50 8.1 uM), a mediator of the unfolded protein response (UPR).1 Under cancer-related hypoxia conditions, ERO1A favors the folding of the angiogenic protein VEGFA leading to cancer cell growth and spread. I2 inhibited the metabolic activity of DMA-MB-231 triple negative breast cancer cells and impaired migration and VEGF secretion. Tumors in C57/BL6Jmice showed decreased levels of VEGF and PD-L1 when treated with I2.

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