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Medchemexpress LLC BioE-1115 | 1268863-35-9 | 98.2% | 10 MG
SDP

Catalog No. 5000338916
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BioE-1115 is a highly selective and potent PAS kinase (PASK) inhibitor with an IC50 of ~4 nM. It also acts as a potent casein kinase 2α inhibitor with an IC50 of ~10 μM.

  • Highly selective PASK inhibitor (IC50 ~4 nM).
  • Potent casein kinase 2α inhibitor (IC50 ~10 μM).
  • Induces dose-dependent loss of PASK phosphorylation in HEK293 cells.
  • Reduces SREBP activity in HepG2 cells without affecting cell morphology or growth.
  • Suppresses SREBP-1c target gene expression and SREBP-1 maturation in liver in vivo.
  • Decreases insulin resistance, hepatic/serum triglycerides, and serum glucose dose-dependently.
  • Does not cause significant changes in liver or body weight.

Catalog No. 50-003-38916 Supplier Medchemexpress LLC Supplier No. HY12957110MG
May include imposed supplier surcharges.
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BioE-1115 is a highly selective and potent PAS kinase (PASK) inhibitor with an IC50 of ~4 nM. It also acts as a potent casein kinase 2α inhibitor with an IC50 of ~10 μM.

  • Highly selective PASK inhibitor (IC50 ~4 nM).
  • Potent casein kinase 2α inhibitor (IC50 ~10 μM).
  • Induces dose-dependent loss of PASK phosphorylation in HEK293 cells.
  • Reduces SREBP activity in HepG2 cells without affecting cell morphology or growth.
  • Suppresses SREBP-1c target gene expression and SREBP-1 maturation in liver in vivo.
  • Decreases insulin resistance, hepatic/serum triglycerides, and serum glucose dose-dependently.
  • Does not cause significant changes in liver or body weight.

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