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Medchemexpress LLC BioE-1115 | 1268863-35-9 | 98.2% | 10 MG
Supplier: Medchemexpress LLC HY12957110MG
BioE-1115 is a highly selective and potent PAS kinase (PASK) inhibitor with an IC50 of ~4 nM. It also acts as a potent casein kinase 2α inhibitor with an IC50 of ~10 μM.
- Highly selective PASK inhibitor (IC50 ~4 nM).
- Potent casein kinase 2α inhibitor (IC50 ~10 μM).
- Induces dose-dependent loss of PASK phosphorylation in HEK293 cells.
- Reduces SREBP activity in HepG2 cells without affecting cell morphology or growth.
- Suppresses SREBP-1c target gene expression and SREBP-1 maturation in liver in vivo.
- Decreases insulin resistance, hepatic/serum triglycerides, and serum glucose dose-dependently.
- Does not cause significant changes in liver or body weight.
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