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Medchemexpress LLC BioE-1115 | 1268863-35-9 | 98.2% | 50 MG
SDP

Supplier:  Medchemexpress LLC HY12957150MG

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BioE-1115 is a highly selective and potent PAS kinase (PASK) inhibitor with an IC50 of approximately 4 nM. It also acts as a potent casein kinase 2α inhibitor with an IC50 of about 10 μM.

  • Highly selective and potent PAS kinase (PASK) inhibitor
  • Potent casein kinase 2α inhibitor
  • Dose-dependent loss of PASK phosphorylation in HEK293 cells
  • Reduces SREBP activity in HepG2 cells
  • Suppresses Gpat1, Fasn, and other SREBP-1c target genes in rats
  • Decreases hepatic expression of lipogenic SREBP-1c target genes
  • Reduces serum triglycerides and partially reverses insulin resistance
  • Decreases HOMA-IR and significantly decreases serum glucose

Catalog No. 50-003-39445


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