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Apexbio Technology LLC Biotin Hydrazide 66640-86-6 500mg
Supplier: Apexbio Technology LLC A8007500
Biotin hydrazide is a hydrazide-functionalized biotin derivative designed to selectively label and detect protein carbonylation an irreversible post-translational modification frequently arising from oxidative stress conditions Protein carbonylation typically results from reactions between protein side chains and reactive oxygen species (ROS) lipid peroxidation metabolites such as -unsaturated -hydroxyalkenals or glycation-mediated oxidative modifications Mechanistically Biotin Hydrazide interacts specifically with protein-bound carbonyl groups through hydrazone formation under mildly acidic conditions (around pH 5 5) without the requirement of additional reducing agents or catalysts Thus Biotin hydrazide facilitates biochemical studies aimed at identifying and characterizing carbonyl-modified proteins in biological samples through biotin-based detection assays and downstream proteomic analysis techniques
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