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Sigma Aldrich Fine Chemicals Biosciences BioTracker NTP Transporter
Supplier: Sigma Aldrich Fine Chemicals Biosciences SCT064
Nucleoside triphosphates (NTPs) are important metabolites that are involved in numerous cellular processes. However due to their anionic nature NTPs do not readily permeate cell membranes. To overcome this barrier synthetic analogues that are neutral and more readily transportable are commonly used in cell-based assays. However these synthetic analogues have a very low efficiency of conversion to active metabolites. Hence there is a need to optimize transport of NTPs into the cells.BioTrackerTMSYMBOL/TMSYMBOL NTP-Transporter Molecule has a receptor site for selectively binding to the NTPs and a cell penetrating agent. The transporter can bind to NTPs and quickly move them into cells without any apparent damage to the cell membrane or decrease in cell viability. The transported NTP is rapidly liberated from the complex and available in the nuclei for incorporation into DNA. Labeled NTPs can be used for live cell imaging cell proliferation assays synthetic biology studies sy
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