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Sigma Aldrich Fine Chemicals Biosciences BioTracker NucViewR 405 Bl

Catalog No. 502906501
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Caspases are a family of protease enzymes that play essential roles in programmed cell death termed apoptosis. Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9 and sequential activation of plays a central role in the execution-phase of cellular apoptosis.The BioTracker NucView 405 Blue Caspase-3 Dye provides a convenient live cell tool for profiling apoptotic cell populations based on caspase-3/7 activity using either fluorescence microscopy or flow cytometry. In contrast to other fluorogenic caspase substrates or fluorescent caspase inhibitor based (fLICA) assays the BioTracker NucView 405 Caspase-3 Dye can be used to detect caspase-3/7 activity within individual intact cells without inhibiting apoptosis progression. The substrate consists of a fluorogenic DNA dye coupled to the caspase-3/7 DEVD recognition sequence. The substrate which is initially non-fluorescent penetrates the plasma membrane and enters the cytoplasm. In apoptotic cells caspase-3/7 cl

Catalog No. 50-290-6501 Supplier Sigma Aldrich Fine Chemicals Biosciences Supplier No. SCT104
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Caspases are a family of protease enzymes that play essential roles in programmed cell death termed apoptosis. Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9 and sequential activation of plays a central role in the execution-phase of cellular apoptosis.The BioTracker NucView 405 Blue Caspase-3 Dye provides a convenient live cell tool for profiling apoptotic cell populations based on caspase-3/7 activity using either fluorescence microscopy or flow cytometry. In contrast to other fluorogenic caspase substrates or fluorescent caspase inhibitor based (fLICA) assays the BioTracker NucView 405 Caspase-3 Dye can be used to detect caspase-3/7 activity within individual intact cells without inhibiting apoptosis progression. The substrate consists of a fluorogenic DNA dye coupled to the caspase-3/7 DEVD recognition sequence. The substrate which is initially non-fluorescent penetrates the plasma membrane and enters the cytoplasm. In apoptotic cells caspase-3/7 cl

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