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Medchemexpress LLC BIP-135 | 941575-71-9 | 99.86% | 421.24 | 50 MG
Supplier: Medchemexpress LLC HY11105550MG
BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. It exhibits a neuroprotective effect.
- Potent and selective ATP-competitive GSK-3 inhibitor
- IC50 for GSK-3α: 16 nM
- IC50 for GSK-3β: 21 nM
- Increases survival motor neuron (SMN) protein levels in human SMA fibroblasts
- Neuroprotective agent in models of oxidative stress
- Well-tolerated in animal studies; non-toxic
- Prolongs median survival time in SMA mouse models
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