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Medchemexpress LLC BIP-135 | 941575-71-9 | 99.9% | 421.24 | 10 MG
Supplier: Medchemexpress LLC HY11105510MG
BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. It exhibits neuroprotective effects.
- Potent and selective ATP-competitive GSK-3 inhibitor.
- Exhibits neuroprotective effect.
- Increases survival motor neuron (SMN) protein levels in human SMA fibroblasts (at 25 μM).
- Superior neuroprotective agent in models of oxidative stress (at 20 μM).
- Prolongs median survival time in a Δ7 SMA KO mouse model of spinal muscular atrophy (at 75 mg/kg; i.p.; daily).
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