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Medchemexpress LLC Biphenylindanone A | 866823-73-6 | C30H30O4 | 1 ML
SDP

Catalog No. 5000376684
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Biphenylindanone A (BINA) is a selective human mGluR2 (hmGluR2) potentiator. It is investigated for its potential application in the treatment of various neurological disorders. In vitro studies show activity on glutamate-induced scintillation proximity assay [3H]IP₁ hydrolysis on WT mGluR2 with an EC50 of 1.57 μM.

  • Acts as a selective mGluR2 potentiator.
  • Demonstrates positive allosteric modulation of rat mGluR2 in HEK-293 cells with an EC50 of 0.38 μM.
  • Shows positive allosteric modulation of rat mGluR2 receptor in HEK293A cells by calcium mobilization assay with an EC50 of 441 nM.
  • Exhibits activity on glutamate-induced scintillation proximity assay [3H]IP₁ hydrolysis on WT mGluR2 (EC50=1.57 μM) in the absence or presence of 5 μM glutamate.

Catalog No. 50-003-76684 Supplier Medchemexpress LLC Supplier No. HY1544210MM/1ML
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Biphenylindanone A (BINA) is a selective human mGluR2 (hmGluR2) potentiator. It is investigated for its potential application in the treatment of various neurological disorders. In vitro studies show activity on glutamate-induced scintillation proximity assay [3H]IP₁ hydrolysis on WT mGluR2 with an EC50 of 1.57 μM.

  • Acts as a selective mGluR2 potentiator.
  • Demonstrates positive allosteric modulation of rat mGluR2 in HEK-293 cells with an EC50 of 0.38 μM.
  • Shows positive allosteric modulation of rat mGluR2 receptor in HEK293A cells by calcium mobilization assay with an EC50 of 441 nM.
  • Exhibits activity on glutamate-induced scintillation proximity assay [3H]IP₁ hydrolysis on WT mGluR2 (EC50=1.57 μM) in the absence or presence of 5 μM glutamate.

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