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Apexbio Technology LLC BIRB 796 (Doramapimod) 285983-48-4 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC A56395.1

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BIRB 796 (Doramapimod CAS 285983-48-4) is a potent inhibitor of human p38 mitogen-activated protein kinase (MAPK) which modulates the signaling pathways associated with inflammatory cytokine production It demonstrates significant inhibition of TNF- release (EC50 18 nM) in THP-1 cells In animal models oral administration reduces LPS-induced TNF- synthesis and ameliorates collagen-induced arthritis severity Clinically however trials for Crohn s disease showed no superiority over placebo BIRB 796 serves as a valuable research tool in inflammation and cytokine signaling studies

Catalog No. 50-000-62439


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