STEMCELL Technologies BIRB-796, Size: 1 mg

Supplier:  STEMCELL Technologies 72682

BIRB-796 is a highly potent inhibitor of p38 MAPK (Kd = 0.1 nM) that blocks TNFα release in LPS-stimulated THP-1 cells (IC₅₀ = 18 nM) (Pargellis et al.). At 10 μM, BIRB-796 can also inhibit JNK2α2 in vitro, but at lower concentrations BIRB-796 inhibits p38 MAPK without affecting phosphorylation of JNK substrates (Bain et al.; Kuma et al.).MAINTENANCE AND SELF-RENEWAL· Rescues the self-renewal ability of muscle satellite cells from aged mice (Bernet et al.).· Increases the regenerative capacity of functional aged skeletal muscle stem cells grown in hydrogel (Cosgrove et al.).· Blocks GADD45G-induced differentiation of long-term repopulating hematopoietic stem cells (Thalheimer et al.).· Enhances stem cell activity of cultured umbilical cord blood-derived hematopoietic cells cultured in serum-free medium supplemented with SCF, TPO, and FLT3L (Baudet et al.).· Blocks the osteogenic differentiation effect of myocilin on human mesenchymal stem cells (Kwon et al.).

Catalog No. 50-197-5961