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Apexbio Technology LLC Birinapant (TL32711) 1260251-31-7 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A42195.1
Birinapant (TL32711) is a potent antagonist of XIAP and cIAP proteins binding specifically to their BIR domains with Kd values around 45 nM for XIAP and below 1 nM for cIAP1 By promoting rapid degradation of TRAF2-associated cIAP1 and cIAP2 Birinapant suppresses TNF-induced NF- B signaling and facilitates the assembly of RIPK1-dependent caspase-8 complexes thus initiating downstream apoptosis pathways It has been widely employed in biomedical research to investigate apoptosis mechanisms and tumor resistance In melanoma and breast cancer models Birinapant combined with cytokines such as TNF- led to tumor cell growth suppression and sensitized therapy-resistant cells to apoptosis
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