Bisindolylmaleimide 1, Thermo Scientific Chemicals

Description

Very potent and selective inhibitor of protein kinase C

Bisindolylmaleimide is used as a highly selective inhibitor of all PKC isoforms and slight inhibitor of GSK-3, used to selectively probe for PKC-mediated pathways for transduction of hormone, cytokine, and growth factor signals, very potent and selective inhibitor of protein kinase C.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Bisindolylmaleimide is used as a highly selective inhibitor of all PKC isoforms and slight inhibitor of GSK-3, used to selectively probe for PKC-mediated pathways for transduction of hormone, cytokine, and growth factor signals, very potent and selective inhibitor of protein kinase C.

Solubility
Insoluble in water.

Notes
Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Specifications

Chemical Identifiers

• CAS: 133052-90-1
• Molecular Formula: C25H24N4O2
• Molecular Weight (g/mol): 412.493
• MDL Number: MFCD00236428
• InChI Key: QMGUOJYZJKLOLH-UHFFFAOYSA-N
• Synonym: bisindolylmaleimide i, unii-l79h6n0v6c, rbt205 inhibitor, gö 6850, bisindolylmaleimide i gf 109203x, bim-1, chembl7463, 2-1-3-dimethylaminopropyl indol-3-yl-3-indol-3-yl maleimide, 3-1-3-dimethylamino propyl-1h-indol-3-yl-4-1h-indol-3-yl-1h-pyrrole-2,5-dione
• PubChem CID: 2396
• ChEBI: CHEBI:41072
• IUPAC Name: 3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
• SMILES: CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54

• Color: Orange
• Quantity: 5 mg
• Solubility Information: Insoluble in water.
• Formula Weight: 412.48
• Physical Form: Crystalline Powder
• Chemical Name or Material: Bisindolylmaleimide 1

Safety and Handling

TSCA	No
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only