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Medchemexpress LLC Bisindolylmaleimide I hydrochloride | 176504-36-2 | 98.4% | 448.94 | 50 MG
Supplier: Medchemexpress LLC HY13867A50MG
Bisindolylmaleimide I hydrochloride is a cell-permeable and reversible PKC inhibitor, with IC50 values of 20 nM for PKCα, 17 nM for PKCβI, 16 nM for PKCβII, and 20 nM for PKCγ. It also functions as a GSK-3 inhibitor. This product is intended for research use only.
- Acts as a cell-permeable and reversible PKC inhibitor
- Inhibits multiple PKC isoforms including alpha, beta I, beta II, and gamma
- Demonstrates activity as a GSK-3 inhibitor
- Capable of inhibiting alpha-thrombin-induced P47 phosphorylation
- Inhibits DNA synthesis in quiescent cells
- Reduces GSK-3 activity in adipocyte lysates
- Inhibits exosome and microvesicle release from PC3 cells
- Enhances the cytotoxicity of 5-fluorouracil
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