Bisindolylmaleimide II, Tocris Bioscience™

Description

Potent PKC inhibitor and nicotinic receptor antagonist

Potent, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 0.01 μM). Displays selectivity for PKC over protein kinase A (PKA) and phosphorylase kinase (PK) (IC50 values are 0.75 and 2μM for PK and PKA respectively). Also displays potent, noncompetitive antagonism at nicotinic cholinergic receptors (IC50 ∽ 0.03 μM for inhibition of catecholamine secretion in nicotine-stimulated PC-12 cells).

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Specifications

Chemical Identifiers

• CAS: 137592-45-1
• Molecular Formula: C27H26N4O2
• Molecular Weight (g/mol): 438.531
• InChI Key: LBFDERUQORUFIN-UHFFFAOYSA-N
• Synonym: bisindolylmaleimide ii, 2-1-2-1-methylpyrrolidino ethyl-1h-indol-3-yl-3-1h-indol-3-yl maleimide, bisindolyl deriv. 22, bim-2, bisindolylmaleimide ii mixture of 2 isomers, 3-1h-indol-3-yl-4-1-2-1-methylpyrrolidin-2-yl ethyl indol-3-yl pyrrole-2,5-dione, 3-1h-indol-3-yl-4-1-2-1-methyl-2-pyrrolidinyl ethyl-1h-indol-3-yl-1h-pyrrole-2,5-dione, 3-1h-indol-3-yl-4-1-2-1-methylpyrrolidin-2-yl ethyl-1h-indol-3-yl-2,5-dihydro-1h-pyrrole-2,5-dione, 3-1h-indol-3-yl-4-1-2-1-methylpyrrolidin-2-yl ethyl indol-3-yl-1h-pyrrole-2,5-dione
• PubChem CID: 2397
• IUPAC Name: 3-(1H-indol-3-yl)-4-[1-[2-(1-methylpyrrolidin-2-yl)ethyl]indol-3-yl]pyrrole-2,5-dione
• SMILES: CN1CCCC1CCN2C=C(C3=CC=CC=C32)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65

• Quantity: 10 mg
• Formula Weight: 438.52
• Percent Purity: >97%
• Chemical Name or Material: Bisindolylmaleimide II

Safety and Handling

Recommended Storage

Store at -20°C