Apexbio Technology LLC BIX 02189 1094614-85-3 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A58015.1

BIX 02189 is a selective kinase inhibitor targeting MEK5 a mitogen-activated protein kinase kinase It belongs to the chemical class of dihydroindolone-based kinase inhibitors Mechanistically BIX 02189 binds and inhibits the catalytic activity of MEK5 leading subsequently to suppression of ERK5 phosphorylation without affecting closely related kinases such as MEK1 MEK2 ERK2 or JNK2 In cellular studies using cultured HeLa and HEK293 cells BIX 02189 inhibits transcriptional activity mediated by downstream substrate MEF2C as well as ERK5 phosphorylation Additionally BIX 02189 has demonstrated inhibition of lymphatic endothelial cell sprouting in three-dimensional lymphangiogenesis assays indicating its applicability in angiogenesis and signal transduction research

Catalog No. 50-000-61823