Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000062304

Apexbio Technology LLC BIX 02565 1311367-27-7 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC B12955.1

Encompass_Preferred

BIX 02565 (CAS 1311367-27-7) is a potent inhibitor of ribosomal S6 kinase 2 (RSK2) showing an IC50 of approximately 1 nM RSK activation typically stimulates Na /H exchanger (NHE) crucial for early cellular stress responses involving intracellular pH regulation calcium handling and potential induction of cardiac hypertrophy BIX 02565 also inhibits adrenergic ( 1A 1B 1D 2A 2) imidazoline I2 LRRK2 and PKD1 receptors at varying potencies (IC50 0 052 1 820 M 16 nM and 35 nM respectively) In vivo studies in rats demonstrated dose-dependent decreases in heart rate and mean arterial pressure This compound aids research into signaling pathways relevant to cardiovascular disorders and kinase biology

Catalog No. 50-000-62304


May include imposed supplier surcharges.
Only null left
Add to Cart

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.