Apexbio Technology LLC BKM120 944396-07-0 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A30155.1

BKM120 (CAS 944396-07-0) is a potent orally bioavailable inhibitor of class I phosphatidylinositol 3-kinases (PI3Ks) specifically targeting the isoforms p110 p110 p110 and p110 with IC50 values of 52 nM 166 nM 262 nM and 116 nM respectively By blocking PI3K activity this molecule suppresses downstream phosphorylation of AKT an important mediator within the PI3K-AKT-mTOR signaling cascade implicated in tumor growth and survival Preclinical studies demonstrate that BKM120 restricts tumor cell proliferation promotes cell cycle arrest at G1 phase and induces apoptosis particularly noted in PTEN-deficient cancer models Thus BKM120 serves as a useful tool for studying PI3K pathway-dependent cancers

Catalog No. 50-000-62987