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Apexbio Technology LLC Bleomycin Sulfate 9041-93-4 50mg
Supplier: Apexbio Technology LLC A833150
Bleomycin sulfate is a glycopeptide antibiotic mixture derived from Streptomyces verticillus exhibiting antitumor activity through induction of DNA strand breaks Its cytotoxic mechanism involves binding to metal ions and forming activated oxygen species that cleave single- and double-stranded DNA Bleomycin-mediated DNA damage inhibits nucleic acid and protein biosynthesis thus affecting cell cycle progression and morphology It is employed in experimental oncology to model chemotherapy-induced DNA lesions cellular damage and associated lung fibrosis in vitro and in vivo Reported IC50 values vary by cell type but typically range from approximately 0 1 to 10 M Bleomycin sulfate is commonly utilized in research studies of Hodgkin s lymphoma squamous cell carcinoma testicular cancer plantar warts and fibrosis-related pulmonary injury models
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