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Medchemexpress LLC Bleximenib (oxalate) | 2866179-95-3 | 98.0% | 689.82 | 5 MG
Supplier: Medchemexpress LLC HY148669A5MG
Bleximenib oxalate is an orally active and selective menin-KMT2A inhibitor. It demonstrates high potency, inhibiting the proliferation and inducing apoptosis and differentiation of tumor cells. This compound is valuable for research into tumors like leukemia.
- Orally active and selective menin-KMT2A inhibitor
- Inhibits proliferation and induces apoptosis and differentiation of tumor cells
- Suitable for research into tumors such as leukemia
- Potent IC50 values (0.1 nM for humans, 0.045 nM for mice, and ≤0.066 nM for dogs)
- Reduces expression of MEIS1, PBX3, FLT3, and JMJD1C in MOLM-14 and OCI-AML3 cells
- Exhibits anti-tumor activity in mouse models of leukemia
- Increases lifespan of mice and expression of differentiation markers in animal models
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