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Medchemexpress LLC Bleximenib (oxalate) | 2866179-95-3 | MFC32H50FN7O3.C2H2O4 | 98.0% | 689.82 | 100 MG
Supplier: Medchemexpress LLC HY148669A100MG
Bleximenib oxalate (JNJ-75276617) is an orally active and selective menin-KMT2A inhibitor. It exhibits IC50 values of 0.1 nM, 0.045 nM, and ≤0.066 nM for humans, mice, and dogs, respectively. This compound can inhibit the proliferation and induce apoptosis and differentiation of tumor cells, making it valuable for research into tumors such as leukemia.
- Orally active and selective menin-KMT2A inhibitor
- Inhibits proliferation of tumor cells
- Induces apoptosis and differentiation of tumor cells
- Exhibits anti-tumor activity in mouse models of leukemia
- Reduces expression of MEIS1, PBX3, FLT3, and JMJD1C in MOLM-14 and OCI-AML3 cells
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