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Apexbio Technology LLC BLZ945 953769-46-5 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B48995.1
BLZ945 (CAS 953769-46-5) is a selective small-molecule inhibitor targeting colony-stimulating factor 1 receptor (CSF-1R) a receptor tyrosine kinase critical for macrophage and osteoclast differentiation proliferation migration and survival in response to macrophage colony-stimulating factor (M-CSF) BLZ945 inhibits CSF-1R kinase activity with an IC50 of 1 2 nM and reduces proliferation of M-CSF-dependent cells in vitro (e g EC50 of 71 M in MNFS-60 cells) In murine tumor models CSF-1R inhibition by BLZ945 reduces tumor-associated macrophage turnover and delays progression of breast and cervical tumors highlighting its utility in cancer and immune research
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