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Apexbio Technology LLC BMH-21(Synonyms: BMH21, BMH 21, CID 46835406, RNA polymerase I inhibitor BMH-21, RNA Pol I inhibitor BMH-21), 200mg, CAS: 896705-16-1.
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Catalog No. 5000060214
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BMH-21 (CAS 896705-16-1) is a planar heterocyclic small molecule DNA intercalator that selectively inhibits RNA polymerase I (Pol I)-mediated transcription It preferentially inserts into GC-rich double-stranded DNA regions leading to Pol I blockade and subsequent degradation of its catalytic subunit RPA194 BMH-21 exhibits cytotoxic activity across various human cancer cell lines independently of the p53 status disrupting nucleolar integrity and RNA synthesis Furthermore BMH-21 promotes p53 expression in epithelial compartments of human prostate tissues demonstrating tissue permeability and highlighting its applicability in anticancer research

Catalog No. 50-000-60214 Supplier Apexbio Technology LLC Supplier No. B4896200
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BMH-21 (CAS 896705-16-1) is a planar heterocyclic small molecule DNA intercalator that selectively inhibits RNA polymerase I (Pol I)-mediated transcription It preferentially inserts into GC-rich double-stranded DNA regions leading to Pol I blockade and subsequent degradation of its catalytic subunit RPA194 BMH-21 exhibits cytotoxic activity across various human cancer cell lines independently of the p53 status disrupting nucleolar integrity and RNA synthesis Furthermore BMH-21 promotes p53 expression in epithelial compartments of human prostate tissues demonstrating tissue permeability and highlighting its applicability in anticancer research

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