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Apexbio Technology LLC BMN-673 8R,9S 1207456-00-5 200mg
Supplier: Apexbio Technology LLC A3246200
BMN-673 8R 9S (CAS 1207456-00-5) is an inactive stereoisomer of BMN-673 a potent poly(ADP-ribose) polymerase 1 and 2 (PARP1/2) inhibitor While BMN-673 demonstrates selective cytotoxicity toward tumor cells with deficiencies in BRCA1 BRCA2 or PTEN exploiting vulnerabilities in DNA repair pathways BMN-673 8R 9S lacks inhibitory activity This renders BMN-673 8R 9S a valuable negative control in studies investigating PARP inhibition mechanisms and differentiating on-target from off-target effects in cellular and in vivo models of DNA repair deficiency Its use supports rigorous evaluation of PARP1/2 inhibitor specificity in translational cancer research
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