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Medchemexpress LLC BMS-191095 | 166095-21-2 | 98.0% | C22H21ClN4O2 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY14256100MG

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BMS-191095 is a selective activator of mitochondrial ATP-sensitive potassium (mitoKATP) channels, inhibiting human platelet aggregation by opening mitochondrial K(ATP) channels. It induces mitochondrial depolarization of vascular smooth muscle (VSM) cells and dose-dependently induces vasodilation in endothelium-denuded cerebral arteries. BMS-191095 also reduces neuronal damage in rats with transient focal cerebral ischemia.

  • Induces mitochondrial depolarization of vascular smooth muscle (VSM) cells.
  • Dose-dependently induces vasodilation in endothelium denuded cerebral arteries.
  • Increases the frequency of calcium sparks in VSM cells.
  • Inhibits human platelet aggregation induced by collagen and thrombin.
  • Reduces neuronal damage in rats with transient focal cerebral ischemia.
  • Reduces total infarct volume and induces rapid mitochondrial depolarization in rats with ischemia.

Catalog No. 50-003-54711


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