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Medchemexpress LLC BMS 299897 | 290315-45-6 | 99.6% | C24H21ClF3NO4S | 1 ML
SDP

Catalog No. 5000358309
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BMS 299897 is a sulfonamide γ-secretase inhibitor with an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).

  • Sulfonamide γ-secretase inhibitor.
  • IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).
  • Reduces levels of Aβ peptides.
  • Shows dose- and time-dependent reductions of amyloid β-peptide (Aβ) in brain, cerebrospinal fluid (CSF), and plasma in young transgenic mice.
  • Attenuates Aβ25-35-induced Aβ1-42 seeding and toxicity.
  • Blocks Aβ25-35-induced deficits in spontaneous alternation or novel object recognition.

Catalog No. 50-003-58309 Supplier Medchemexpress LLC Supplier No. HY5088310MM/1ML
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BMS 299897 is a sulfonamide γ-secretase inhibitor with an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).

  • Sulfonamide γ-secretase inhibitor.
  • IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).
  • Reduces levels of Aβ peptides.
  • Shows dose- and time-dependent reductions of amyloid β-peptide (Aβ) in brain, cerebrospinal fluid (CSF), and plasma in young transgenic mice.
  • Attenuates Aβ25-35-induced Aβ1-42 seeding and toxicity.
  • Blocks Aβ25-35-induced deficits in spontaneous alternation or novel object recognition.

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