Medchemexpress LLC BMS 299897 | 290315-45-6 | 99.6% | C24H21ClF3NO4S | 5 MG

Supplier:  Medchemexpress LLC HY508835MG

BMS 299897 is a sulfonamide γ-secretase inhibitor that inhibits Aβ production with an IC50 of 7 nM in HEK293 cells overexpressing amyloid precursor protein (APP).

• Reduces levels of Aβ peptides.
• Decreases Aβ peptides to 20-50% of vehicle control at 1 μM.
• Reduces retrograde QD-BDNF signals, increases anterograde signals.
• Shows dose- and time-dependent reductions of Aβ in brain, CSF, and plasma in mice.
• Reduces brain and plasma Aβ1-40.
• Increases brain concentrations of APP-carboxy-terminal fragments.
• Attenuates Aβ25-35-induced Aβ1-42 seeding and toxicity.
• Blocks Aβ25-35-induced deficits in spontaneous alternation or novel object recognition.

Catalog No. 50-003-59020