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Medchemexpress LLC BMS-303141 | 943962-47-8 | 99.0% | 424.30 | 50 MG
SDP

Catalog No. 5000395198
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BMS-303141 is a potent, cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC50 of 0.13 μM. It is intended for research use only and is not sold to patients.

  • Potent, cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC50 of 0.13 μM.
  • In HepG2 cells, shows inhibition of total lipid synthesis with an IC50 of 8 μM.
  • Exhibits no cytotoxicity up to 50 μM in a cell-based Alamar Blue cytotoxicity assay.
  • In high-fat fed mice, lowers plasma cholesterol and triglycerides by approximately 20-30%.
  • Reduces fasting plasma glucose by 30-50% in high-fat fed mice.
  • Shows gradual inhibition of weight gain and reduction in adiposity without affecting food intake.
  • Has an oral bioavailability of 55% and a half-life of 2.1 hours.

Catalog No. 50-003-95198 Supplier Medchemexpress LLC Supplier No. HY1610750MG
May include imposed supplier surcharges.
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BMS-303141 is a potent, cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC50 of 0.13 μM. It is intended for research use only and is not sold to patients.

  • Potent, cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC50 of 0.13 μM.
  • In HepG2 cells, shows inhibition of total lipid synthesis with an IC50 of 8 μM.
  • Exhibits no cytotoxicity up to 50 μM in a cell-based Alamar Blue cytotoxicity assay.
  • In high-fat fed mice, lowers plasma cholesterol and triglycerides by approximately 20-30%.
  • Reduces fasting plasma glucose by 30-50% in high-fat fed mice.
  • Shows gradual inhibition of weight gain and reduction in adiposity without affecting food intake.
  • Has an oral bioavailability of 55% and a half-life of 2.1 hours.

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