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Apexbio Technology LLC BMS-345541(free base)(Synonyms: BMS 345541, BMS345541, BMS-345541, IKK Inhibitor III, IKK-1/IKK-2 inhibitor), 5mg, CAS: 445430-58-0.
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Catalog No. 502240025
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BMS-345541 (free base CAS 445430-58-0) is a selective inhibitor of I B kinases IKK-1 and IKK-2 central enzymes involved in cytokine-induced NF- B signaling It inhibits IKK-1 and IKK-2 with reported IC50 values of approximately 4 M and 0 3 M respectively In cell-based assays utilizing THP-1 monocytes pretreatment with BMS-345541 decreases cytokine-induced phosphorylation of IKK and suppresses production of inflammatory cytokines including TNF- IL-1 IL-6 and IL-8 Additionally in glioma and melanoma cell lines this compound reduces proliferation and induces apoptotic cell death BMS-345541 serves as a relevant pharmacological tool for studying IKK-NF- B pathway modulation and disease mechanisms involving inflammation or apoptosis

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Catalog No. 50-224-0025 Supplier Apexbio Technology LLC Supplier No. B46555
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BMS-345541 (free base CAS 445430-58-0) is a selective inhibitor of I B kinases IKK-1 and IKK-2 central enzymes involved in cytokine-induced NF- B signaling It inhibits IKK-1 and IKK-2 with reported IC50 values of approximately 4 M and 0 3 M respectively In cell-based assays utilizing THP-1 monocytes pretreatment with BMS-345541 decreases cytokine-induced phosphorylation of IKK and suppresses production of inflammatory cytokines including TNF- IL-1 IL-6 and IL-8 Additionally in glioma and melanoma cell lines this compound reduces proliferation and induces apoptotic cell death BMS-345541 serves as a relevant pharmacological tool for studying IKK-NF- B pathway modulation and disease mechanisms involving inflammation or apoptosis

This item is not returnable. View return policy
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