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Apexbio Technology LLC BMS-599626 Hydrochloride 873837-23-1 100mg
Supplier: Apexbio Technology LLC A3252100
BMS-599626 Hydrochloride (CAS 873837-23-1) is a selective small-molecule inhibitor targeting the human epidermal growth factor receptors HER1 (EGFR) and HER2 exhibiting IC50 values of 22 nM and 32 nM respectively By antagonizing these receptor tyrosine kinases BMS-599626 disrupts downstream signaling pathways involved in cellular proliferation and survival In vitro the compound inhibits proliferation of breast tumor cell lines overexpressing HER1 or HER2 but shows limited effects on cells lacking these receptors In vivo oral administration in murine xenograft models suppresses tumor growth in a dose-dependent manner BMS-599626 is valuable for studying HER-mediated oncogenic signaling and targeted therapy development
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